How genetic variants influence human fertility?

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We may never think about it, although human biology influences numerous aspects of our life. Even how many children you will have is also related to biology. A study conducted recently considered one of the largest focuses on genetics, human biology, and such elements to identify the reason behind the fertility rate among women. The study highlighted important aspects of human evolution and the human genome leverages natural selection and even fertility among women.

The study was conducted in collaboration with innumerable experts from Oxford, Cambridge, and Pennsylvania. The researchers pointed out that fertility is something that is connected to various mechanisms of human biology. These mechanisms are a contributing factor in the diversity of fertility.  Not just fertility but everything else such as sex hormone levels, puberty as every person has at different times, the age of menopause, endometriosis, etc. You may find it difficult to digest but it is also connected to our behavior as you may have noticed that some people are great at taking risks some are not, it is connected to biology.

One of the researchers from the study Professor Melinda Mills who is the director of Oxford Leverhulme Centre for demographic science discussed how the analysis is based on the notion to understand the changing pattern of reproduction, from the early ages to the present time, the relationship between biology and how it can be connected to infertility.

The researchers accumulated data from ancient genomes and incorporated them with modern genomes to identify the variation that has occurred from the time.  They find out that the genome has certain sections goes under change, under selection from ancient times to the present.

The region where the genes, specifically FADS1 and FADS2 are engaged in synthesizing a certain kind of fats. This fat is essential for keeping our health in check apart from that the second role of it, is to adopt the agricultural diet In Europe. This was involved in helping to adapt agricultural-based diets specifically in Europe. The finding from the research is that these genes are still adapting which makes us understand two fundamental things about it, first, the adaption is still going on, and the process is not ending, second that gene still affecting fertility.

The other expert from the Department of Genetics, University of Pennsylvania, USA, Dr. Lain Mathieson. Highlighted that the gene we are discussing is under the process of natural selection, it shows that historically it was going through selection and presently too.

The offspring you will have in the future is connected to biology the number of children is also associated with the genes.  This analysis executed newly evaluated one of the enormous emphases on genetics, and human biology to identify, fertility and its changing pattern.

Genetic variants influencing human fertility identified – new. (2023, March 2). https://www.ox.ac.uk/news/2023-03-02-genetic-variants-influencing-human-fertility-identified-new-research

Genetic variants influencing human fertility identified – university. (2023, March 2). https://www.ox.ac.uk/news/2023-03-02-genetic-variants-influencing-human-fertility-identified-university-study Ding, X., & Schimenti, J. C. (2021). Strategies to Identify Genetic Variants Causing Infertility. Trends in molecular medicine27(8), 792–806. https://doi.org/10.1016/j.molmed.2020.12.008

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